The doctors of Seattle Grace Hospital deal with life-or-death consequences on a daily basis -- it's in one another that they find comfort, friendship and, at times, more than friendship.
24 episodes are available in this season.
Season five kicks off with a romance for Cristina, a reality check for Meredith and Derek and some harsh news for the hospital.
Meredith and Derek discover the downsides to their renewed relationship, and Cristina continues to lust after the new military doctor.
A plumbing leak soon becomes a full on flood at the hospital, George retakes his residency exam and Derek puts his stamp on Meredith's house.
Meredith is thrown into panic when her mother's diary is discovered, while Callie stresses over her impending first date with Erica.
Bailey leads the team in a 'domino procedure' where each operation is dependent on the one before it. Meanwhile, Meredith is overlooked at work.
Bailey is given extra responsibility and a highly difficult operation to work on. Meanwhile, Owen's methods prove unpopular with the other staff.
The residents compete for the chance to perform a solo surgery, while Derek seeks Bailey's advice on relationship issues.
Meredith's friend Sadie begins an internship at the hospital but is welcomed with less than open arms, and Lexie leads a novel training session.
Meredith, Cristina and Bailey step in when a routine surgery goes drastically wrong, and Owen and Derek treat an injured sleepwalker.
Cristina wins the first solo surgery but is forced to give it up, while Mark heads up a procedure that could restore a patient's ability to speak.
Bailey pairs up with a new surgeon to operate on a young patient, while Derek is enraged when a death row inmate is checked into the hospital.
Meredith meets Derek's mother for the first time, Owen & Cristina go on their first date, and the death row inmate decides to donate his organs.
Bailey rushes to find an organ donor for a rapidly declining patient, Mark finds himself in a compromising position and Cristina tries to avoid Owen.
Derek plans his proposal to Meredith, Lexie pushes Mark to go public with their relationship and Bailey contemplates pursuing a new career direction.
Private Practice stars Kate Walsh, Andra McDonald and Taye Diggs guest when Addison, Naomi & Sam rush Archer to Seattle Grace for emergency surgery.
Bailey receives some harsh words from the Chief, Derek squares up against Addison and Cristina questions a renowned surgeon.
After hearing shocking statistics relating to his practice, Derek decides to quit. Bailey continues to fight for her pediatrics fellowship.
Meredith tries to convince Derek to return to work, and Izzie opens up about her condition. Elsewhere, Mark attempts a rare face transplant.
Tensions run high as Derek returns to the surgery room after his breakdown, while Izzie faces surgery herself.
Izzie continues to endure aggressive cancer treatment, while trying to distract herself by planning Derek and Meredith's wedding.
A person from Meredith's past reappears as she and Derek prepare for their wedding day, and Izzie receives a visit from her mother.
As Meredith, Derek and their guests gather for their wedding, a group of college students are admitted to the ER following a car crash.
Izzie makes some vital decisions after spending time with a fellow cancer patient. Mark considers turning his relationship with Lexie up a gear.
The team wait for Izzie to recover from surgery, George reveals shocking news and a traffic accident brings a devastating conclusion to season five.
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