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The History of Criminalistics. Poisons and Toxicology (2014) Ever since the first person died of poisoning, people have been trying to figure out ways to prove criminal intent. Poisons caused symptoms similar to those of a deadly decease and there was no known way to detect a poison in a human. In the 19th century, however, Mathieu Joseph Orfila managed to systematize knowledge of numerous toxic substances and refined the testing technique.

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